Title: Erythrocyte sodium and potassium transport systems during longterm administration of the diuretic xipamide in men
Authors: Lijnen, Paul ×
Amery, A #
Issue Date: Sep-1989
Series Title: Methods and findings in experimental and clinical pharmacology vol:11 issue:9 pages:587-94
Abstract: The effects of xipamide on the intracellular concentration and transmembrane fluxes of Na+ and K+ were studied in twenty-four normal sodium-replete or -deplete male subjects, using a double-blind study design. After a run-in period on placebo for 1 week on their regular diet, subjects were treated on their regular diet or on a low-sodium diet with either placebo or xipamide 20 mg once a day for 16 weeks. Intra-erythrocyte Na+ concentration was increased during xipamide administration in sodium-replete and deplete subjects, while intra-erythrocyte K+ and total intraleukocyte Ca2+ concentrations were decreased. Red cell Na+, K+-cotransport activity was lower in xipamide-treated subjects, while Na+, Li-countertransport activity was increased. No significant effect of xipamide could be demonstrated on ouabain-sensitive 86Rb-uptake or on maximal [3H]-ouabain binding in erythrocytes.
ISSN: 0379-0355
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Hypertension and Cardiovascular Epidemiology
× corresponding author
# (joint) last author

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