Efficacy of Recombinant Human Interleukin-10 in Prevention of Post-Endoscopic Retrograde Cholangiopancreatography Pancreatitis in Subjects With Increased Risk
Sherman, Stuart × Cheng, Chi-Liang Costamagna, Guido Binmoeller, Kenneth F Puespoek, Andreas Aithal, Guruprasad P Kozarek, Richard A Chen, Yang K Van Steenbergen, Werner Tenner, Scott Freeman, Martin Monroe, Paul Geffner, Michael Deviere, Jacques #
Lippincott williams & wilkins
Pancreas vol:38 issue:3 pages:267-274
Objectives: Pancreatitis is the most common major complication of endoscopic retrograde cholangiopancreatography (ERCP). Inflammatory cytokines are released during acute pancreatitis. Interleukin-10 (IL-10) is a potent inhibitor of cytokines and has been shown to attenuate pancreatitis in animal models and pilot human studies. This study aimed to determine whether prophylactic IL-10 administration reduces the frequency and/or severity of post-ERCP pancreatitis in high-risk patients.