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Title: In vivo soft tissue damage assessment for applications in surgery
Authors: Famaey, Nele ×
Verbeken, Eric
Vinckier, Stefan
Willaert, Bert
Herijgers, Paul
Vander Sloten, Jos #
Issue Date: Jun-2010
Publisher: Butterworth-Heinemann
Series Title: Medical Engineering & Physics vol:32 issue:5 pages:437-443
Abstract: In robotic and conventional minimally invasive surgery the risk of complications caused by collateral tissue damage remains high. This paper studies the concept of imposing damage thresholds on surgical instruments, to avoid tissue overload. More specifically, the paper investigates the correlation between mechanical loading and damage in case of vascular clamping.
With a computer controlled device, a high and a low clamping load were applied in vivo on the abdominal aorta of 43 rats. Samples of both loading levels were compared with control samples and with samples clamped by a
mosquito clamp w.r.t. functionality and histological integrity.
Analysis of the samples shows that the high clamping force results in endothelial and smooth muscle cell destruction. Clamping with a mosquito clamp will cause even more damage to the elastic lamellae. Samples loaded at the lower load showed significantly less smooth muscle cell damage and a lower degree of endothelial damage.
This paper shows that there is a clear correlation between the degree of mechanical loading and the degree of tissue damage, justifying the need for tissue overload prevention during surgery. Future experiments will also include the effects of loading duration, recovery and patient-specificity.
ISSN: 1350-4533
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Biomechanics Section
Translational Cell & Tissue Research
Vesalius Research Centre (-)
Production Engineering, Machine Design and Automation (PMA) Section
Experimental Cardiac Surgery
× corresponding author
# (joint) last author

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