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Title: Frizzled-PDZ scaffold interactions in the control of Wnt signaling
Authors: Wawrzak, Danuta
Luyten, Annouck
Lambaerts, Kathleen
Zimmermann, Pascale # ×
Issue Date: 2009
Publisher: Symposium Publications Division, Pergamon Press
Host Document: Advances in Enzyme Regulation vol:49 issue:49 pages:98-106
Abstract: Wnt signaling pathways are essential for embryonic patterning and are disturbed in a wide spectrum
of diseases, including cancer. An unresolved question is how the different Wnt pathways are
supported and regulated. Here, we review how the PDZ domain-interacting C-terminal region of the
Wnt receptor Frizzled can impact on the outcome of Wnt signaling. PDZ domains are interaction
domains often found in multi-domain scaffolding proteins. PDZ scaffolds assemble specific proteins
into large molecular complexes at defined locations in the cell but can also regulate the dynamic
trafficking of target proteins. The impact of PDZ proteins in Wnt signaling has probably been underinvestigated
and further studies might help to understand several unresolved aspects.
ISSN: 0065-2571
Publication status: published
KU Leuven publication type: IC
Appears in Collections:Department of Human Genetics - miscellaneous
Molecular Genetics Section (-)
Laboratory for Signal Integration in Cell Fate Decision
Translational Research in GastroIntestinal Disorders
× corresponding author
# (joint) last author

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