Title: A mutation of the mitochondrial ABC transporter Sta1 leads to dwarfism and chlorosis in the Arabidopsis mutant starik
Authors: Kushnir, Sergei ×
Babiychuk, Elena
Storozhenko, Sergei
Davey, Mark
Papenbrock, J
De Rycke, R
Engler, Gilbert
Stephan, U.W.
Lange, H
Kispal, G
Lill, R
Van Montagu, Marc #
Issue Date: Jan-2001
Publisher: Amer soc plant physiologists
Series Title: Plant cell vol:13 issue:1 pages:89-100
Abstract: A mutation in the Arabidopsis gene STARIK leads to dwarfism and chlorosis of plants with an altered morphology of leaf and cell nuclei. We show that the STARIK gene encodes the mitochondrial ABC transporter Stal that belongs to a subfamily of Arabidopsis half-ABC transporters. The severity of the starik phenotype is suppressed by the ectopic expression of the STA2 homolog; thus, Stal function is partially redundant, Stal supports the maturation of cytosolic Fe/S protein in Delta atm1 yeast, substituting for the ABC transporter Atm1p, Similar to Atm1p-deficient yeast, mitochondria of the starik mutant accumulated more nonheme, nonprotein iron than did wild-type organelles, We further show that plant mitochondria contain a putative L-cysteine desulfurase. Taken together, our results suggest that plant mitochondria possess an evolutionarily conserved Fe/S cluster biosynthesis pathway, which is linked to the intracellular iron homeostasis by the function of Atm1p-like ABC transporters.
ISSN: 1040-4651
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Division of Crop Biotechnics
× corresponding author
# (joint) last author

Files in This Item:
File Description Status SizeFormat
2001, Davey Kushnir 2001 Plant Cell ABC transporter.pdfMain article Published 610KbAdobe PDFView/Open Request a copy

These files are only available to some KU Leuven Association staff members


All items in Lirias are protected by copyright, with all rights reserved.

© Web of science