Title: Jak2 is essential for signaling through a variety of cytokine receptors
Authors: Parganas, E
Wang, D
Stravopodis, D
Topham, DJ
Marine, Chris
Teglund, S
Vanin, EF
Bodner, S
Colamonici, OR
van Deursen, JM
Grosveld, G
Ihle, JN # ×
Issue Date: May-1998
Publisher: MIT Press
Series Title: Cell vol:93 issue:3 pages:385-395
Abstract: A variety of cytokines activate receptor-associated members of the Janus family of protein tyrosine kinases (Jaks). To assess the role of Jak2, we have derived Jak2-deficient mice. The mutation causes an embryonic lethality due to the absence of definitive erythropoiesis. Fetal liver myeloid progenitors, although present based on the expression of lineage specific markers, fail to respond to erythropoietin, thrombopoietin, interleukin-3 (IL-3), or granulocyte/macrophage colony-stimulating factor. In contrast, the response to granulocyte specific colony-stimulating factor is unaffected. Jak2-deficient fibroblasts failed to respond to interferon gamma (IFN gamma), although the responses to IFN alpha/beta and IL-6 were unaffected. Lastly, reconstitution experiments demonstrate that Jak2 is not required for the generation of lymphoid progenitors, their amplification, or functional differentiation. Therefore, Jak2 plays a critical, nonredundant role in the function of a specific group of cytokines receptors.
ISSN: 0092-8674
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Non-KU Leuven Association publications
× corresponding author
# (joint) last author

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