Regulation of SIRT6 protein levels by nutrient availability
Kanfi, Yariv Shalman, Ronnie Peshti, Victoria Pilosof, Shmuel N Gozlan, Yosi M Pearson, Kevin J Lerrer, Batya Moazed, Danesh Marine, Chris de Cabo, Rafael Cohen, Haim Y # ×
Elsevier on behalf of the Federation of European Biochemical Societies
FEBS Letters vol:582 issue:5 pages:543-548
Sirtuins have been shown to regulate life-span in response to nutritional availability. We show here that levels of the mammalian sirtuin, SIRT6, increased upon nutrient deprivation in cultured cells, in mice after fasting, and in rats fed a calorie-restricted diet. The increase in SIRT6 levels is due to stabilization of SIRT6 protein, and not via an increase in SIRT6 transcription. In addition, p53 positively regulates SIRT6 protein levels under standard growth conditions but has no role in the nutrient-dependent regulation of SIRT6. These observations imply that at least two sirtuins are involved in regulation of life-span by nutrient availability. (C) 2008 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.