Title: Phospholipase C gamma 2 is essential in the functions of B cell and several Fc receptors
Authors: Wang, DM
Feng, J
Wen, RR
Marine, Chris
Sangster, MY
Parganas, E
Hoffmeyer, A
Jackson, CW
Cleveland, JL
Murray, PJ
Ihle, JN # ×
Issue Date: Jul-2000
Publisher: Cell Press
Series Title: Immunity vol:13 issue:1 pages:25-35
Abstract: Many receptors activate phospholipase C gamma 1 or -gamma 2. To assess the role of PLC gamma 2, we derived enzyme-deficient mice. The mice are viable but have decreased mature B cells, a block in pro-B cell differentiation, and B1 B cell deficiency. IgM receptor-induced Ca2+ flux and proliferation to B cell mitogens are absent. IgM, IgG2a, and IgG3 levels are reduced, and T cell-independent antibody production is absent. The similarity to Btk- or Blnk-deficient mice demonstrates that PLC gamma 2 is downstream in Btk/Blnk signaling. FcR gamma signaling is also defective, resulting in a loss of collagen-induced platelet aggregation, mast cell Fc epsilon R function, and NK cell Fc gamma RIII and 2B4 function. The results define a signal transduction pathway broadly utilized by immunoglobulin superfamily receptors.
ISSN: 1074-7613
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Non-KU Leuven Association publications
× corresponding author
# (joint) last author

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