Chromosomal location of fifteen unique mouse KRAB-containing zinc finger loci
Marine, Chris Gilbert, DJ Bellefroid, EJ Martial, JA Ihle, JN Copeland, NG Jenkins, NA # ×
Mammalian genome vol:7 issue:6 pages:413-416
The mammalian genome contains hundreds if not thousands of zinc finger protein (ZSp) genes. While the function of most of these genes remains to be determined, it is clear that a few of them play important roles in gene regulation and development. In studies described here, we have used an interspecific mouse backcross mapping panel to determine the chromosomal location of 15 KRAB-containing zinc finger loci. These loci map to nine different mouse autosomes and the X Chromosome (Chr). Two Chrs, 7 and 9, contain cosegregating pairs of KRAB-containing Zfp genes, indicating that the KRAB-containing Zfp genes have evolved through processes involving regional as well as genome-wide duplication events.