Title: Parabutoporin, a cationic amphipathic peptide from scorpion venom: much more than an antibiotic
Authors: Remijsen, Quinten
Verdonck, Fons
Willems, Jean # ×
Issue Date: 26-Oct-2009
Publisher: Elsevier
Series Title: Toxicon vol:55 issue:2-3 pages:180-185
Article number: PMID: 19874840
Abstract: Parabutoporin (PP) from the South African scorpion Parabuthus schlechteri is a 45-mer lysine-rich and cysteine-free peptide. At micromolar concentrations it has antimicrobial effects against G+ and G- bacteria and is antifungal as well.
However, at submicromolar concentrations, parabutoporin also directly interferes with cellular functions of the human innate immune system, especially polymorphonuclear neutrophils (PMN): parabutoporin acts as a chemoattractant for neutrophils, induces their degranulation, while delaying constitutive neutrophil apoptosis. In addition, it potently inhibits induced superoxide production.
Different signalling pathways regulating these biochemical processes were identified as targets of parabutoporin. Therefore, parabutoporin is a well documented scorpion venom peptide with immuno-regulatory properties beyond its antibiotic effects.
ISSN: 0041-0101
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Faculty of Medicine, Campus Kulak Kortrijk
Microbiology and Immunology, Campus Kulak Kortrijk
Department of Microbiology & Immunology - miscellaneous
× corresponding author
# (joint) last author

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