Title: Dynamic MR perfusion measurements before and after TIPS in cirrhotic patients with refractory ascites
Authors: Maleux, Geert ×
De Keyzer, Frederik
Prinsloo, Jeannine
Heye, Sam
Nevens, Frederik
Marchal, Guy #
Issue Date: Nov-2007
Publisher: Association of University Radiologists
Series Title: Academic Radiology vol:14 issue:11 pages:1400-1408
Abstract: RATIONALE AND OBJECTIVES: We sought to assess changes in liver perfusion parameters induced by transjugular intrahepatic portosystemic shunt (TIPS) creation in cirrhotic patients with refractory ascites using dynamic MR perfusion measurements. MATERIALS AND METHODS: MR perfusion measurements were performed before and after TIPS creation in 15 cirrhotic patients all with refractory ascites. Measurements were performed over a time period of 120 seconds providing 60 images for each examination and calculations were done in both liver and splenic parenchyma. Different perfusion parameters were assessed: time to peak (TTP), time to inflow deceleration (TID), maximal or peak perfusion (C-peak) and the wash-in rate. RESULTS: TIPS procedures were successful in all 15 patients but were complicated by hepatic encephalopathy in 3 patients (20%), and in another 4 patients (26%), persistent refractory ascites was still noted during follow-up. Overall, liver TID values decreased significantly (P = .001) after TIPS creation; liver wash-in values increased significantly (P = .04) after TIPS. TTP values did not decrease significantly (P = .16) and liver C-peak values did not change equally (P = .99). CONCLUSION: In cirrhotic patients with refractory ascites, TIPS induced a faster, but not an increased, contrast enhancement in the liver.
ISSN: 1076-6332
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Hepatology
× corresponding author
# (joint) last author

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