Title: Vitamin D, parathyroid hormone and the metabolic syndrome in middle-aged and older European men
Authors: Lee, David ×
Rutter, Martin
O'Neill, Terence
Boonen, Steven
Vanderschueren, Dirk
Bouillon, Roger
Bartfai, Gyorgy
Casanueva, Felipe
Finn, Joseph
Forti, Gianni
Giwercman, Aleksander
Han, Thang
Huhtaniemi, Ilpo
Kula, Krzysztof
Lean, Michael
Pendleton, Neil
Punab, Margus
Silman, Alan
Wu, Fredrick #
Issue Date: Dec-2009
Publisher: BioScientifica Ltd.
Series Title: European Journal of Endocrinology vol:161 issue:6 pages:947-954
Abstract: Objectives: Low serum 25-hydroxyvitamin D (25(OH)D) and elevated parathyroid (PTH) levels have been linked to insulin resistance, the metabolic syndrome (MetS) and its components. Data in healthy, community-dwelling Europeans are lacking and previous studies have not excluded subjects receiving drug treatments that may distort the relationship between 25(OH)D/PTH and MetS. The aim of our analysis was to examine the association of 25(OH)D and PTH with Adult Treatment Panel III-defined MetS in middle-aged and older European men. Design: This was a population-based, cross-sectional study of 3,369 men aged 40-79 years enrolled in the European Male Aging Study (EMAS). Results: After exclusion of subjects with missing data, 3,069 men with a mean (+/-SD) age of 60+/-11 years were included in the analysis. Age-adjusted 25(OH)D levels were inversely associated with waist circumference, systolic BP, triglycerides and glucose (all <italic>P</italic><0.01). Age-adjusted PTH levels were only associated with waist and diastolic BP (both <italic>P</italic><0.05). After adjusting for age, centre, season and lifestyle factors the odds for MetS decreased across increasing 25(OH)D quintiles (OR 0.48 [95%CI 0.36-0.64] highest vs. lowest quintile; <italic>P</italic><sub>trend</sub><0.001). This relationship was unchanged after adjustment for PTH, but was attenuated after additional adjustment for HOMA-IR (0.60 [0.47-0.78]; <italic>P</italic><sub>trend</sub><0.001). There was no association between PTH and MetS. Conclusions: Our results demonstrate an inverse relationship between 25(OH)D levels and MetS which is independent of several confounders and PTH. The relationship is partly explained by insulin resistance. The clinical significance of these observations warrants further study.
ISSN: 0804-4643
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Clinical and Experimental Endocrinology
Gerontology and Geriatrics
× corresponding author
# (joint) last author

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