Title: Effectiveness and safety of sirolimus-eluting stents in the treatment of restenosis after coronary stent placement
Authors: Neumann, Franz-Josef ×
Desmet, Walter
Grube, Eberhard
Brachmann, Johannes
Presbitero, Patrizia
Rubartelli, Paolo
Mügge, Andreas
Di Pede, Francesco
Füllgraf, Diana
Aengevaeren, Wim
Spedicato, Leonardo
Popma, Jeffrey J #
Issue Date: Apr-2005
Series Title: Circulation vol:111 issue:16 pages:2107-11
Abstract: BACKGROUND: In-stent restenosis is notoriously difficult to treat by repeat catheter intervention because of its propensity for aggressive recurrent neointimal formation. This study sought to assess the effectiveness and safety of the sirolimus-eluting stent in the treatment of in-stent restenosis. METHODS AND RESULTS: The study was designed as a prospective multicenter registry. We included 162 patients with in-stent restenosis of a native coronary artery who had a clinical indication for repeat intervention. Patients were scheduled for follow-up angiography at 6 months. The primary end point was in-lesion late loss. Follow-up angiography was performed in 155 patients. We obtained an in-lesion late loss of 0.08+/-0.49 mm and a binary restenosis rate of 9.7% (15/155), which prompted reintervention in 7.4% (12/162) at 9 months. The 9-month rate of death was 1.2% (2/162) and that of nonfatal myocardial infarction was 1.2% (2/162). CONCLUSIONS: Sirolimus-eluting stents were highly efficacious and safe in the treatment of in-stent restenosis. Our study provides rationale for the use of sirolimus-eluting stents in the treatment of in-stent restenosis.
ISSN: 0009-7322
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Cardiology
× corresponding author
# (joint) last author

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