Author:

Keywords:

Adolescent, circulating mature lymphocytes, Adult, skin allograft survival, Aged, immunosuppressant fty720, Cadaver, mycophenolate-mofetil, Cyclosporine, acute rejection, Dose-Response Relationship, Drug, graft-survival, cyclosporine, Drug Therapy, Combination, rats, Humans, allotransplantation, Immunosuppressive Agents, pharmacodynamics, Kidney Transplantation, Middle Aged, Propylene Glycols, Safety, Sphingosine, Tissue Donors, Treatment Outcome, Science & Technology, Life Sciences & Biomedicine, Immunology, Surgery, Transplantation, CIRCULATING MATURE LYMPHOCYTES, SKIN ALLOGRAFT SURVIVAL, IMMUNOSUPPRESSANT FTY720, CYCLOSPORINE, PHARMACODYNAMICS, SEQUESTRATION, ACCELERATION, COMBINATION, RATS, Fingolimod Hydrochloride, 11 Medical and Health Sciences, 3202 Clinical sciences, 3204 Immunology

Abstract:

BACKGROUND: FTY720 is the first of a new drug class: sphingosine-1-phosphate receptor agonist. Its effect relates to the modulation of lymphocytes trafficking from blood and peripheral tissues to lymph nodes. This is the first study to evaluate the efficacy and safety of FTY720 in de novo renal transplantation. METHODS: This phase 2a, multicenter, open-label, dose-finding study compared FTY720 (0.25, 0.5, 1.0, or 2.5 mg) with mycophenolate mofetil (MMF), in combination with cyclosporine and corticosteroids. Patients (n=208) received FTY720 (n=167) or MMF (n=41) for 3 months followed by a 3-month follow-up. RESULTS: The incidence of biopsy-confirmed acute rejection at month 3 was 23.3%, 34.9%, 17.5%, and 9.8%, respectively, with FTY720 at doses of 0.25, 0.5, 1.0, and 2.5 mg, versus 17.1% with MMF. The incidence for the composite endpoint (biopsy-confirmed acute rejection, graft loss, or death) was lowest with FTY720 at a dose of 2.5 mg at month 3 (14.6%) compared with FTY720 at doses of 0.25 mg (25.6%), 0.5 mg (34.9%), and 1.0 mg (17.5%), and MMF (19.5%). Safety was comparable between FTY720 and MMF group. The main difference in tolerability was a mild and transient reduction in heart rate. A decrease in peripheral lymphocytes occurred in patients receiving FTY720, as expected from the mode of action, and this was reversible after treatment cessation. CONCLUSIONS: FTY720 at 2.5 mg was found to be as effective as MMF in combination with cyclosporine for the prevention of acute rejection after renal transplantation. FTY720 was well tolerated and not associated with the side effects commonly observed with immunosuppressant therapies.