Title: Progression and improvement after mild cognitive impairment
Authors: Buntinx, Frank ×
Paquay, Louis
Ylieff, Michel
De Lepeleire, Jan #
Issue Date: 2009
Publisher: Archives Belges de Médecine Sociale / Belgisch Archief van Sociale Geneeskunde
Series Title: Archives of Public Health vol:67 pages:7-14
Abstract: Objective
We studied progression to dementia and improvement rates of mild cognitive impairment
(MCI) to help clinicians decide whether or not to screen older people for MCI.
Prospective cohort study in which 156 vulnerable patients with (n=24) and without (n=132)
MCI are followed and reassessed after two years with MMSE and Camdex.
Nine (38%) out of 24 patients initially diagnosed with MCI and 20 (15%) out of 132 considered
normal or depressed progressed to dementia within two years. This results in a relative
risk of progression of 2.48 (95% confidence interval=1.29-4.77), a sensitivity of 31%
(95%CI=16-51) and a predictive value of 38% (95%CI=20-59). Out of 24 people with MCI at
baseline, 8 (33%; 95%CI=16-55) had improved at follow-up.
The low sensitivity of MCI for subsequent occurrence of dementia and the high improvement
rate found in our study as well as by others, and the absence of a proven therapy, provide
cumulative evidence against screening for MCI.
ISSN: 0778-7367
VABB publication type: VABB-1
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Academic Center for General Practice
× corresponding author
# (joint) last author

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