Title: Differential responses of plasma aldosterone, cortisol and adrenocorticotropin to two dopamine receptor antagonists
Authors: Staessen, Jan ×
Fiocchi, R
Bouillon, Roger
Fagard, Robert
Lijnen, Paul
Lissens, W
Amery, A #
Issue Date: Oct-1985
Publisher: Prous
Series Title: Methods and findings in experimental and clinical pharmacology vol:7 issue:10 pages:523-7
Abstract: The response of plasma aldosterone, cortisol and adrenocorticotropin (ACTH) to the dopamine antagonists metoclopramide and domperidone, administered intravenously in a dose of 1 mg/kg, was investigated in healthy volunteers. Within 15 min after metoclopramide administration, plasma aldosterone (+ 99%), cortisol (+ 75%) and ACTH (+ 55%) increased (p less than 0.001), whereas the plasma levels of these hormones were not altered after domperidone. The differential responses of plasma aldosterone and cortisol to high doses of metoclopramide and domperidone are therefore, at least partially, mediated via the enhanced adrenal stimulation by ACTH after metoclopramide.
ISSN: 0379-0355
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Hypertension and Cardiovascular Epidemiology
Clinical and Experimental Endocrinology
× corresponding author
# (joint) last author

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