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Title: Analysis of basic Helix-loop-Helix protein function in nervous system development of Drosophila melanogaster
Other Titles: Analysen van de functie van basic Helix-loop-Helix proteinen bij de ontwikkeling van het Drosophila melanogaster zenuwstelsel
Authors: Hu, Shu; S0111305
Issue Date: 26-Nov-2009
Table of Contents: Table of contents

Summary 3
Samenvatting 5
Professional career: Shu Hu 7
Acknowledgement 8
List of abbreviation 10
Introduction 11
Basic helix loop helix proteins 11
Neural bHLH proteins and proneural proteins 12
Proneural protein-dependent neuronal diversity in the fly PNS 16
Atonal related proteins and their functions 17
Ato proneural functions in the fly PNS 21
Chordotonal organ formation 21
Auditory system formation 22
Olfactory system formation 23
Compound eye formation 24
1, Recruitment of ommatidial cells 26
2, Photoreceptor axon extension and targeting 30
3, Photoreceptor morphogenesis 33
4, Retinotopic map formation by synaptogenesis 35
Drosophila as a genetic research model 37
Objectives 48
Part One: Screen for ato Interacting Genes 49
Materials and Methods 49
Results 50
Discussion & perspectives 62
Part Two: Tap Functional Analysis 65
Introduction 65
Materials and Methods 66
Results 77
Discussion & perspectives 100
Reference 106
Publication status: published
KU Leuven publication type: TH
Appears in Collections:Molecular Genetics Section (-)
Department of Human Genetics - miscellaneous

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