Title: Diffusion weighted imaging in small rodents using clinical MRI scanners
Authors: Chen, Feng ×
De Keyzer, Frederik
Wang, Huaijun
Vandecaveye, Vincent
Landuyt, Willy
Bosmans, Hilde
Hermans, Robert
Marchal, Guy
Ni, Yicheng #
Issue Date: Sep-2007
Publisher: Academic Press
Series Title: Methods vol:43 issue:1 pages:12-20
Abstract: Diffusion weighted imaging (DWI) has emerged as a unique and powerful non-invasive magnetic resonance imaging (MRI) technique with a major potential impact on imaging-based diagnosis in a variety of clinical applications including oncology and tissue viability assessment. In light of increasing demand for applying this technique in preclinical investigations using small animals, we have explored the potentials of a clinical magnet for acquiring the DWI in rats and mice with either cerebral ischemia or solid tumors. Through technical adaptation and optimization, we have been able to perform a series of clinically relevant animal studies with conclusions based on DWI quantification. Focusing more on practical aspects and cross-referencing with the current literature, this paper is aimed to summarize our ongoing DWI studies on small rodents with stroke and tumors, and to provide protocols for researchers to replicate similar techniques in their own preclinical and clinical studies.
ISSN: 1046-2023
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Radiology
Theragnostic Laboratory (+)
Translational MRI (+)
× corresponding author
# (joint) last author

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