Title: Design, synthesis and antiHIV activity of novel isatine-sulphonamides
Authors: Selvam, P ×
Murugesh, N
Chandramohan, M
Debyser, Zeger
Witvrouw, M #
Issue Date: Nov-2008
Publisher: Medknow publications
Series Title: Indian journal of pharmaceutical sciences vol:70 issue:6 pages:779-782
Abstract: A series of novel isatine-sulphonamide derivatives have been synthesized by combining isatin derivatives with sulphonamides. The structure of the synthesized compounds were elucidated by spectral analysis (IR, NMR and Mass). Investigation of anti-HIV activity was done against HIV-1(IIIB) in MT-4 cells and HIV integrase inhibitory activity. 4-(1-acetyl-5-methyl-2-oxoindolin-3-ylideneamino)-N-(4,6-dimethylpyrimidin-2-yl) benzenesulfonamide (SPIII-5ME-AC) inhibits the HIV Integrase enzymatic activity as both over all and strand transfer reaction and 4-(1-benzoyl-5-chloro-2-oxoindolin-3-ylideneamino)-N-(4,6-dimethylpyrimidin-2-yl) benzene sulfonamide (SPIII5Cl-BZ) exhibits 36 percent maximum protection against HIV-1 at sub toxic concentration.
ISSN: 0250-474X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Virology and Gene Therapy
× corresponding author
# (joint) last author

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