Title: The role of placental growth factor in the nervous system
Authors: Dhondt, Joke
Verheyen, An
Poesen, Koen
Van Damme, Philip
Peeraer, Eve
Beerens, Manu
Ver Elst, Joke
Nijs, Martine
De Mol, Maria
Jansen, Alexandra
Van Dyck, Ester
Hagens, Hélène
Nuydens, Rony
Meert, Theo
Robberecht, Wim
Carmeliet, Peter
Lambrechts, Diether #
Issue Date: 2008
Conference: VIB seminar location:Blankenberge date:5-6 March 2008
Abstract: The placental growth factor (PlGF) is a member of the VEGF family. This family also includes VEGF and VEGF-B. VEGF exerts most of its effects on nerves and vessels through its receptor Flk1. It is, however, also able to bind to another receptor, Flt1. Unlike VEGF, PlGF and VEGF-B only bind to Flt1. We recently discovered a novel neuroprotective role for Flt1 in the nervous system (VIB abstract Koen Poesen) and therefore investigated the relevance of PlGF in the motoneuron and sensory nervous system.
Publication status: published
KU Leuven publication type: AMa
Appears in Collections:Vesalius Research Centre (-)
Research Group Experimental Neurology
Molecular and Vascular Biology
Laboratory for Neurobiology
Laboratory of Translational Genetics (VIB-KU Leuven Center for Cancer Biology)
Laboratory of Angiogenesis and Vascular Metabolism (VIB-KU Leuven Centre for Cancer Biology) (+)
# (joint) last author

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