Title: Effect of aspirin on renal function and the prostaglandin-kallikrein systems early after myocardial infarction
Authors: Lijnen, Paul ×
Boelaert, J
Van Eeghem, P
Daneels, R
Schurgers, M
De Jaegere, P
Van der Stichele, E
Vincke, J
Verschueren, L J
Amery, A #
Issue Date: May-1984
Series Title: Journal of cardiovascular pharmacology vol:6 issue:3 pages:455-9
Abstract: Using a double-blind procedure, 29 patients with a recent myocardial infarction were randomly allocated to a placebo group (n = 14) and to a group receiving aspirin, 300 mg three times a day (n = 15) over 7 days. No change in renal function was observed in either treatment group. Compared with the placebo group, the 24-h urinary excretion of prostaglandin E2 (PGE2) was significantly suppressed in the aspirin group, but the urinary kallikrein activity was unchanged. These results contrast with our previous study of similar patients, in which sulfinpyrazone decreased renal function, as well as the urinary PGE2 and kallikrein excretions. These divergent effects of aspirin and sulfinpyrazone on urinary kallikrein activity could explain the different trends in renal function observed early after myocardial infarction.
ISSN: 0160-2446
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Hypertension and Cardiovascular Epidemiology
× corresponding author
# (joint) last author

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