Title: Prevalence of CARD15/NOD2 mutations in Caucasian healthy people
Authors: Hugot, Jean-Pierre ×
Zaccaria, Isabelle
Cavanaugh, Juleen
Yang, Huiying
Vermeire, Severine
Lappalainen, Maarit
Schreiber, Stefan
Annese, Vito
Jewell, Derek P
Fowler, Elizabeth V
Brant, Steven R
Silverberg, Mark S
Cho, Judy
Rioux, John D
Satsangi, Jack
Parkes, Miles #
Issue Date: Jun-2007
Publisher: Nature Publishing Group
Series Title: American Journal of Gastroenterology vol:102 issue:6 pages:1259-1267
Abstract: BACKGROUND: Crohn's disease (CD) has been associated with CARD15/NOD2 mutations in Caucasians. The R702W, G908R, and 1007fs mutations represent 82% of the mutated chromosomes. The relative risk of developing CD in homozygous or compound heterozygous people has been estimated as between 10 and 40 times that of the general population. This high risk may support the opinion that CARD15/NOD2 variants are strong CD risk factors at the individual and population levels.
ISSN: 0002-9270
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Translational Research in GastroIntestinal Disorders
× corresponding author
# (joint) last author

Files in This Item:

There are no files associated with this item.

Request a copy


All items in Lirias are protected by copyright, with all rights reserved.

© Web of science