Prevalence of CARD15/NOD2 mutations in Caucasian healthy people
Hugot, Jean-Pierre × Zaccaria, Isabelle Cavanaugh, Juleen Yang, Huiying Vermeire, Severine Lappalainen, Maarit Schreiber, Stefan Annese, Vito Jewell, Derek P Fowler, Elizabeth V Brant, Steven R Silverberg, Mark S Cho, Judy Rioux, John D Satsangi, Jack Parkes, Miles #
Nature Publishing Group
American Journal of Gastroenterology vol:102 issue:6 pages:1259-1267
BACKGROUND: Crohn's disease (CD) has been associated with CARD15/NOD2 mutations in Caucasians. The R702W, G908R, and 1007fs mutations represent 82% of the mutated chromosomes. The relative risk of developing CD in homozygous or compound heterozygous people has been estimated as between 10 and 40 times that of the general population. This high risk may support the opinion that CARD15/NOD2 variants are strong CD risk factors at the individual and population levels.