Serological markers are associated with disease course in ulcerative colitis. A study in an unselected population-based cohort followed for 10 years
Hoie, Ole × Aamodt, Geir Vermeire, Severine Bernklev, Tomm Odes, Selwyn Wolters, Frank L Riis, Lene Politi, Patrizia Tsianos, Epameinondas V Butron, Mercedes Stockbrugger, Reinhold W Munkholm, Pia Vatn, Morten Moum, Bjorn #
Elsevier Science BV
Journal of Crohns & Colitis vol:2 issue:2 pages:114-122
Objectives: Perinuclear anti-neutrophil cytoplasmic antibody (p-ANCA) and anti-Saccharomyces cerevisiae antibody (ASCA) have been proposed as markers for diagnosis and for subtyping of inflammatory bowel disease (IBD). The aim of this study was to investigate the association of p-ANCA and ASCA with a 10-year disease outcome in terms of cumulative rate of colectomy and relapse in a population-based European inception cohort of ulcerative colitis (UC) patients.