Title: Switch from systemic steroids to budesonide in steroid-dependent patients with inactive Crohn's disease
Authors: Cortot, A
Colombel, JF
Rutgeerts, Paul
Lauritsen, K
Malchow, H
Hamling, J
Winter, T
Van Gossum, Anna
Persson, T
Pettersson, E #
Issue Date: 2000
Publisher: Prous Science
Host Document: Drugs of Today vol:36 pages:33-37
Conference: Clinical Symposium on the Inflammatory Bowel Disease on the Doctor in Focus location:Montreux, Switzerland date:4-5 Feb 2000
Abstract: This trial evaluated the possibility of switching from systemic steroids to budesonide (Entocort(R)) in prednisolone/prednisone-dependent patients with inactive Crohn's disease affecting the ileum and/or the ascending colon. In a double-blind, multicenter trial, 120 patients were randomly assigned to receive budesonide 6 mg once daily or placebo. Prednisolone was tapered to zero during the first 4-10 weeks and budesonide or placebo was given concomitantly and after cessation of prednisolone for a further 12 weeks. Relapse was defined as a Crohn's disease activity index >200 and an increase of 60 points from baseline or withdrawal due to disease deterioration. It was found that after 1 and 13 weeks without prednisolone, the relapse rates were 17% and 32%, respectively, in the budesonide group and 41% and 65% in the placebo group (p = 0.004 and p < 0.001, respectively). The number or glucocorticosteroid side effects was reduced by 50% by switching from prednisolone and was similar in the budesonide and the placebo groups. The majority of patients with steroid-dependent ileocecal Crohn's disease may be switched to 6 mg budesonide controlled ileal release capsules without relapse, resulting in a sharp decrease in glucocorticosteroid side effects.
ISSN: 0025-7656
Publication status: published
KU Leuven publication type: IC
Appears in Collections:Translational Research in GastroIntestinal Disorders
# (joint) last author

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