Title: Detection of antisynthetic mannoside antibodies (A Sigma MA) reveals heterogeneity in the ASCA response of Crohn's disease patients and contributes to differential diagnosis, stratification, and prediction
Authors: Khoury, Peggy Vandewalle-El ×
Colombel, Jean-Frederic
Joossens, Sofie
Standaert-Vitse, Annie
Collot, Mayeul
Halfvarson, Jonas
Ayadi, Ali
Landers, Carol J
Vermeire, Severine
Rutgeerts, Paul
Targan, Stephan R
Chamaillard, Mathias
Mallet, Jean-Maurice
Sendid, Boualem
Poulain, Daniel #
Issue Date: Apr-2008
Publisher: Nature Publishing Group
Series Title: American Journal of Gastroenterology vol:103 issue:4 pages:949-957
Abstract: OBJECTIVES: Anti-S. cerevisiae mannan antibodies (ASCA) are human antibodies associated with Crohn's disease (CD) reacting with Saccharomyces cerevisiae (S. cerevisiae) mannan polymer. As mannan is a complex and variable repertoire of oligomannoses acting as epitopes, we chemically synthesized (Sigma) two major oligomannose epitopes, Man alpha-1,3 Man alpha-1,2 Man (Sigma Man3) and Man alpha-1,3 Man alpha-1,2 Man alpha-1,2 Man (Sigma Man4), and then explored how antisynthetic mannoside antibodies (A Sigma MA) compare with ASCA as markers of CD.
ISSN: 0002-9270
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Translational Research in GastroIntestinal Disorders
× corresponding author
# (joint) last author

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