Title: Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease
Authors: Barrett, Jeffrey C ×
Hansoul, Sarah
Nicolae, Dan L
Cho, Judy H
Duerr, Richard H
Rioux, John D
Brant, Steven R
Silverberg, Mark S
Taylor, Kent D
Barmada, M. Michael
Bitton, Alain
Dassopoulos, Themistocles
Datta, Lisa Wu
Green, Todd
Griffiths, Anne M
Kistner, Emily O
Murtha, Michael T
Regueiro, Miguel D
Rotter, Jerome I
Schumm, L. Philip
Steinhart, A. Hillary
Targan, Stephan R
Xavier, Ramnik J
Libioulle, Cecile
Sandor, Cynthia
Lathrop, Mark
Belaiche, Jacques
Dewit, Olivier
Gut, Ivo
Heath, Simon
Laukens, Debby
Mni, Myriam
Rutgeerts, Paul
Van Gossum, Andre
Zelenika, Diana
Franchimont, Denis
Hugot, Jean-Pierre
de Vos, Martine
Vermeire, Severine
Louis, Edouard
Cardon, Lon R
Anderson, Carl A
Drummond, Hazel
Nimmo, Elaine
Ahmad, Tariq
Prescott, Natalie J
Onnie, Clive M
Fisher, Sheila A
Marchini, Jonathan
Ghori, Jilur
Bumpstead, Suzannah
Gwilliam, Rhian
Tremelling, Mark
Deloukas, Panos
Mansfield, John
Jewell, Derek
Satsangi, Jack
Mathew, Christopher G
Parkes, Miles
Georges, Michel
Daly, Mark J #
Issue Date: Aug-2008
Publisher: Nature Publishing Group
Series Title: Nature Genetics vol:40 issue:8 pages:955-962
Abstract: Several risk factors for Crohn's disease have been identified in recent genome-wide association studies. To advance gene discovery further, we combined data from three studies on Crohn's disease ( a total of 3,230 cases and 4,829 controls) and carried out replication in 3,664 independent cases with a mixture of population-based and family-based controls. The results strongly confirm 11 previously reported loci and provide genome-wide significant evidence for 21 additional loci, including the regions containing STAT3, JAK2, ICOSLG, CDKAL1 and ITLN1. The expanded molecular understanding of the basis of this disease offers promise for informed therapeutic development.
ISSN: 1061-4036
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Translational Research in GastroIntestinal Disorders
× corresponding author
# (joint) last author

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