Title: IgG1 heavy chain-coding gene polymorphism (G1m allotypes) and development of antibodies-to-infliximab
Authors: Magdelaine-Beuzelin, Charlotte ×
Vermeire, Severine
Goodall, Margaret
Baert, Filip
Noman, Maja
Van Assche, Gert
Ohresser, Marc
Degenne, Danielle
Dugoujon, Jean-Michel
Jefferis, Roy
Rutgeerts, Paul
Lefranc, Maire-Paule
Watier, Herve #
Issue Date: May-2009
Publisher: Lippincott Williams & Wilkins
Series Title: Pharmacogenetics and Genomics vol:19 issue:5 pages:383-387
Abstract: Objective The chimeric anti-tumor necrosis factor-alpha antibody infliximab is known to induce antibodies-to-infliximab (ATI) in some treated patients. Immunogenicity in murine variable domains is expected; however, constant domains of its human heavy gamma 1 chain may also be implicated as it expresses G1m1 and G1m17 allotypes. This allelic form may be immunogenic in patients that are homozygous for the G1m3 allotype commonly expressed in Caucasoid populations.
ISSN: 1744-6872
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Translational Research in GastroIntestinal Disorders
× corresponding author
# (joint) last author

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