G Protein-Coupled Receptor APJ and Its Ligand Apelin Act Downstream of Cripto to Specify Embryonic Stem Cells Toward the Cardiac Lineage Through Extracellular Signal-Regulated Kinase/p70S6 Kinase Signaling Pathway
D'Aniello, Cristina Lonardo, Enza Iaconis, Salvatore Guardiola, Ombretta Liguoro, Anna Maria Liguori, Giovanna L Autiero, Monica Carmeliet, Peter Minchiotti, Gabriella # ×
Lippincott williams & wilkins
Circulation research vol:105 issue:3 pages:231-U65
Rationale: Pluripotent stem cells represent a powerful model system to study the early steps of cardiac specification for which the molecular control is largely unknown. The EGF-CFC (epidermal growth factor-Cripto/FRL-1/Cryptic) Cripto protein is essential for cardiac myogenesis in embryonic stem cells (ESCs).