Title: Mechanisms of vessel branching: filopodia on endothelial tip cells lead the way
Authors: De Smet, Frederik
Segura-Vitutia, Inmaculada
De Bock, Katrien
Hohensinner, Philipp
Carmeliet, Peter # ×
Issue Date: May-2009
Series Title: Arteriosclerosis, Thrombosis and Vascular Biology vol:29 issue:5 pages:639-649
Abstract: Filopodia, "the fingers that do the walking," have been identified on endothelial cells at the tip of sprouting vessels for half a century, but the key role of the tip cell in vessel branching has been recognized only in the past few years. A model is emerging, whereby tip cells lead the way in a branching vessel, stalk cells elongate the sprout, and a very recently discovered phalanx cell ensures quiescence and perfusion of the newly formed branch. Recent genetic studies have shed light on the molecular signature of these distinct endothelial phenotypes; this provides a novel conceptual framework of how vessel morphogenesis occurs. Here, we will discuss the molecular candidates that participate in the decision of endothelial cells to adapt these distinct fates and highlight the emerging insights on how these cells send out filopodia while navigating.
ISSN: 1079-5642
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Vesalius Research Centre (-)
Switch Laboratory
Laboratory of Angiogenesis and Vascular Metabolism (VIB-KU Leuven Centre for Cancer Biology) (+)
× corresponding author
# (joint) last author

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