Title: Branching morphogenesis and antiangiogenesis candidates: tip cells lead the way
Authors: Carmeliet, Peter
De Smet, Frederik
Loges, Sonja
Mazzone, Max # ×
Issue Date: Jun-2009
Publisher: Nature Publishing Group
Series Title: Nature Reviews. Clinical Oncology vol:6 issue:6 pages:315-326
Abstract: From the original concepts that tumors require a vascular supply to grow and that blocking angiogenesis could suppress tumor growth, the oncology field has witnessed clinical successes of VEGF-targeted antiangiogenic medicine. The field is now facing the challenge of overcoming resistance to VEGF-targeted therapy, and therefore additional angiogenesis inhibitors are being developed. Studies on how endothelial 'tip, stalk and phalanx cells' form sprouts have identified promising candidate targets with complementary mechanisms to VEGF. This Review provides a conceptual framework in which molecular discoveries and principles are discussed in light of clinical opportunities to develop new antiangiogenic agents.
ISSN: 1759-4774
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Vesalius Research Centre (-)
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Laboratory of Tumor Inflammation and Angiogenesis (Vesalius Research Center) (+)
Laboratory of Angiogenesis and Vascular Metabolism (Vesalius Research Center) (+)
× corresponding author
# (joint) last author

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