Title: Regulation of Osteogenesis-Angiogenesis Coupling by HIFs and VEGF
Authors: Schipani, Ernestina ×
Maes, Christa
Carmeliet, Geert
Semenza, Gregg L #
Issue Date: Aug-2009
Publisher: Amer soc bone & mineral res
Series Title: Journal of bone and mineral research vol:24 issue:8 pages:1347-1353
Abstract: Bone is a highly vascularized tissue, but the function of angiogenesis in bone modeling and remodeling is still poorly defined, and the molecular mechanisms that regulate angiogenesis in bone are only partially elucidated. Genetic manipulations in mice have recently highlighted the critical role of the hypoxia-inducible-factor/vascular endothelial growth factor pathway in coupling angiogenesis and osteogenesis. In this brief perspective, we review the current understanding of the mechanisms responsible for this coupling. Elucidation of such mechanisms will expand our knowledge of bone development and homeostasis, and it may aid in the design of new therapies for accelerating bone regeneration and repair. J Bone Miner Res 2009;24:1347-1353. Published online on June 29, 2009; doi: 10.1359/JBMR.090602
ISSN: 0884-0431
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Clinical and Experimental Endocrinology
× corresponding author
# (joint) last author

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