Title: Electrophysiological characterization of BmK MI, an alpha-like toxin from Buthus martensi Karsch vernom
Authors: Goudet, Cyril
Huys, Isabelle
Clynen, Elke
Schoofs, Liliane
Wang, DC
Waelkens, Etienne
Tytgat, Jan # ×
Issue Date: Apr-2001
Publisher: Elsevier on behalf of the Federation of European Biochemical Societies
Series Title: FEBS Letters vol:495 issue:1-2 pages:61-65
Abstract: The present study investigates the electrophysiological actions of BmK M1, an alpha-like toxin purified from the venom of the scorpion Buthus martensi Karsch, on voltage-gated Na+ channels. Using the voltage clamp technique, we assessed the BmK M1 activity on the cardiac Na+ channel (hH1) functionally expressed in Xenopus oocytes. The main actions of the toxin are a concentration-dependent slowing of the inactivation process and a hyperpolarizing shift of the steady-state inactivation. This work is the first electrophysiological characterization of BmK M1 on a cloned Na+ channel, demonstrating that this toxin belongs to the class of scorpion alpha-toxins. Our results also show that BmK M1 can be considered as a cardiotoxin.
ISSN: 0014-5793
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Protein Phosphorylation and Proteomics
Animal Physiology and Neurobiology Section - miscellaneous
Toxicology and Pharmacology
Research Centre for Pharmaceutical Care and Pharmaco-economics (-)
Laboratory of Phosphoproteomics (-)
× corresponding author
# (joint) last author

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