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Title: Enigma homolog 1 scaffolds protein kinase D1 to regulate the activity of the cardiac L-type voltage-gated calcium channel
Authors: Maturana, Andres D ×
Waelchli, Sebastien
Iwata, Miki
Ryser, Stephan
Van Lint, Johan
Hoshijima, Masahiko
Schlegel, Werner
Ikeda, Yasuhiro
Tanizawa, Katsuyuki
Kuroda, Shun'ichi #
Issue Date: Jun-2008
Publisher: Oxford univ press
Series Title: Cardiovascular Research vol:78 issue:3 pages:458-465
Abstract: Aims In cardiomyocytes, protein kinase D1 (PKD1) plays a central role in the response to stress signals. From a yeast two-hybrid assay, we have identified Enigma Homolog 1 (ENH1) as a new binding partner of PKD1. Since in neurons, ENH1, associated with protein kinase C epsilon, was shown to modulate the activity of N-type calcium channels, and the pore-forming subunit of the cardiac L-type voltage-gated calcium channel, alpha 1C, possesses a potential phosphorylation site for PKD1, we studied here a possible role of ENH1 and PKD1 in the regulation of the cardiac L-type voltage-gated calcium channel.
ISSN: 0008-6363
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Protein Phosphorylation and Proteomics
× corresponding author
# (joint) last author

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