Enigma homolog 1 scaffolds protein kinase D1 to regulate the activity of the cardiac L-type voltage-gated calcium channel
Authors:
Maturana, Andres D × Waelchli, Sebastien Iwata, Miki Ryser, Stephan Van Lint, Johan Hoshijima, Masahiko Schlegel, Werner Ikeda, Yasuhiro Tanizawa, Katsuyuki Kuroda, Shun'ichi #
Issue Date:
Jun-2008
Publisher:
Oxford univ press
Series Title:
Cardiovascular Research vol:78 issue:3 pages:458-465
Abstract:
Aims In cardiomyocytes, protein kinase D1 (PKD1) plays a central role in the response to stress signals. From a yeast two-hybrid assay, we have identified Enigma Homolog 1 (ENH1) as a new binding partner of PKD1. Since in neurons, ENH1, associated with protein kinase C epsilon, was shown to modulate the activity of N-type calcium channels, and the pore-forming subunit of the cardiac L-type voltage-gated calcium channel, alpha 1C, possesses a potential phosphorylation site for PKD1, we studied here a possible role of ENH1 and PKD1 in the regulation of the cardiac L-type voltage-gated calcium channel.
