Title: A systematic assessment of radiation dose enhancement by 5-aza-2 '-deoxycytidine and histone deacetylase inhibitors in head-and-neck squamous cell carcinoma
Authors: De Schutter, Harlinde ×
Kimpe, Marlies
Isebaert, Sofie
Nuyts, Sandra #
Issue Date: Mar-2009
Publisher: Elsevier science inc
Series Title: International journal of radiation oncology biology physics vol:73 issue:3 pages:904-912
Abstract: Purpose: Investigations of epigenetic drugs have shown that radiotherapy can be successfully combined with histone deacetylase inhibitors (HDAC-Is) for the treatment of head-and-neck squamous cell carcinoma (HNSCC). Whether the reversal of epigenetic silencing by demethylating agents with or without HDAC-Is can also act as radiosensitizing remains unclear. This study therefore aimed to investigate whether 5-aza-2'-deoxycytidine (DAC) alone or in combination with the HDAC-Is trichostatin A, LBH589, or MGCD0103 could radiosensitize HNSCC tumor cell lines.
ISSN: 0360-3016
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Experimental Radiotherapy
Laboratory for Molecular Cell Biology (-)
× corresponding author
# (joint) last author

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