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Title: Peroxisomes, Myelination, and Axonal Integrity in the CNS
Authors: Baes, Myriam ×
Aubourg, Patrick #
Issue Date: Aug-2009
Publisher: Sage publications inc
Series Title: Neuroscientist vol:15 issue:4 pages:367-379
Abstract: Peroxisomes are ubiquitous organelles with multiple metabolic functions, but their precise role in the maintenance of tissues is not well understood. All diseases caused by partial or complete peroxisome dysfunction are characterized by a variety of neurological abnormalities, underscoring the importance of peroxisomes in nervous tissue. The interrelationship between metabolic abnormalities, histological changes, and clinical signs in these peroxisomal diseases has not yet been clarified. During the past decade, a more systematic study of the consequences of peroxisome dysfunction was possible through the generation of knockout mice with generalized or conditional inactivation of peroxisomal proteins. It appears that peroxisomes are necessary for the preservation of axonal integrity and for the formation and maintenance of myelin.
ISSN: 1073-8584
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Cell Metabolism
× corresponding author
# (joint) last author

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