Title: Establishment of reference values for immunoglobulins in the cryoprecipitate
Authors: Vermeersch, Pieter
Gijbels, Koenraad
Knockaert, Daniel
Blockmans, Daniel Engelbert
Westhovens, Rene
Marien, Godelieve
Bossuyt, Xavier # ×
Issue Date: Nov-2008
Publisher: Academic Press
Series Title: Clinical Immunology vol:129 issue:2 pages:360-364
Abstract: Cryoglobulins are often estimated by determining cryocrit or total protein content in the cryoprecipitate, but these are only indirect measures. Direct quantification of immunoglobulins in combination with agarose gel electrophoresis, to appreciate the presence of other proteins in the cryoprecipitate, offers a more sensitive and specific tool for confirming the diagnosis of cryoglobulinemia. Using such strategy, we established reference values for immunoglobulins in cryoprecipitate in diseased controls and applied them to 214 consecutive patients. The 97.5th percentile for IgA, IgG and IgM in diseased controls was 2, 11 and 26 mg/L serum, respectively. The distribution of the 49 positive patients (23%) was 10% type I, 33% type IIa, 16% type IIb, and 41% type III. Complement C4 was decreased in 61% and 55% of the patients classified as type II and type III compared to 16% of the patients that were negative for cryoglobulins and 9% of the diseased controls.
ISSN: 1521-6616
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory for Clinical Infectious and Inflammatory Disorders
Rheumatology Section (-)
Laboratory of Clinical Bacteriology and Mycology
Experimental Laboratory Immunology
× corresponding author
# (joint) last author

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