Title: Non-adherence, The Blind Spot in Glaucoma Research: Results of the Belgian Compliance Study in Ophthalmology
Authors: Vandenbroeck, Sofie ×
Dobbels, Fabienne
De Geest, Sabina
Stalmans, Ingeborg
Zeyen, Thierry #
Issue Date: 2007
Conference: Ophthalmologia Belgica location:Brussels, Belgium date:28-30 Nov 2007
Abstract: Favorable outcomes of glaucoma are dependent on the patient’s ability to adhere with prescribed eye drops. Yet, adherence studies are usually single-center studies, including a small number of patients. The goal of the BSCO-study was to substantiate the magnitude of non-adherence (NA) with eye drops in a large sample of glaucoma patients and to determine a possible association with selected demographic & treatment characteristics


A cross-sectional survey was performed in 827 glaucoma patients treated in 81 centers in Belgium. NA was assessed anonymously using a written self-report questionnaire developed for the purpose of this study. Patients were asked how many times they had forgotten to administer eye drops during the past 2 weeks and had 4 answer options: never, seldom, once a week or daily. Due to underreport of NA using self-report strategy, the most stringent definition of NA “missing 1 or more doses in the past 2 weeks” was used


663 out of 827 (80%) questionnaires were available for analyses. 39.2% of the patients admitted not being adherent to their treatment. Significantly more male (p=0.005) and younger patients (p<0.007) were NA. A high number of daily doses (p=0.001) and low visit frequency (p=0.029) were also associated with NA. Those results remained stable after multivariate analysis.


A substantial proportion of glaucoma patients had problems with NA similar to previous evidence in smaller samples. Correlates of NA were male gender, younger patients, more doses and a low visit frequency. Clinicians should regularly screen for NA during routine follow-up. Patients at risk should be referred for adherence enhancing interventions.
Publication status: accepted
KU Leuven publication type: AMa
Appears in Collections:Academic Centre for Nursing and Midwifery
Research Group Ophthalmology
Interfaculty Centre for Biomedial Ethics and Law
× corresponding author
# (joint) last author

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