Title: An outbreak of hepatitis A associated with the consumption of raw beef
Authors: Robesyn, Emmanuel ×
de Schrijver, Koen
Wollants, Elke
Top, Geert
Verbeeck, Jannick
Van Ranst, Marc #
Issue Date: Mar-2009
Publisher: Elsevier science bv
Series Title: Journal of clinical virology vol:44 issue:3 pages:207-210
Abstract: BACKGROUND: In July 2004, a sharp increase of hepatitis A, a notifiable disease in Belgium, was detected. OBJECTIVES: We investigated the outbreak in order to identify the source and take appropriate action. STUDY DESIGN: We conducted an outbreak investigation which included a matched case-control study to analyse the association with a range of food items and food providers. A phylogenetic analysis was used to study the relation between the outbreak cases and the identified source. RESULTS: We registered 269 cases of hepatitis A. Consumption of raw beef (OR 16.0; 95% CI 2.1-120.7) was the most probable way of infection. A food handler working at an epidemiologically linked meat distribution plant had contracted hepatitis A 1 month before the start of the outbreak. HAV strains from the food handler and the patients involved in the outbreak were monophyletically related. CONCLUSIONS: Since serological immunity in Belgium is decreasing over time, foodborne outbreaks of hepatitis A are a substantial risk. In this outbreak, a single food handler, at the level of the distribution chain, has been identified as the most likely source, through cross-contamination of raw beef. This outbreak investigation suggests the need to consider vaccination against hepatitis A in food handlers.
ISSN: 1386-6532
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Clinical and Epidemiological Virology (Rega Institute)
× corresponding author
# (joint) last author

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