ITEM METADATA RECORD
Title: Development and validation of a liquid chromatographic method for the analysis of capreomycin sulfate and its related substances
Authors: Mallampati, Swapna
Huang, Shan
Mamade, Dunge Ashenafi
Van Hemelrijck, Elise
Hoogmartens, Jos
Adams, Erwin # ×
Issue Date: Mar-2009
Publisher: Elsevier science bv
Series Title: Journal of Chromatography A vol:1216 issue:12 pages:2449-2455
Abstract: A gradient LC method for the analysis of capreomycin sulfate and its related substances was developed. The chromatographic conditions include the use of a Hypersil base deactivated C-18 (250 mm x 4.6 mm, 5 mu m) column maintained at 25 degrees C, a mobile phase containing aceronitrile, phosphate buffer pH 2.3 and 0.025 M hexanesulfonate at a flow rate of 1.0 mL/min and UV detection performed at 268 nm. Good separation of the four active components of capreomycin and eleven unknown impurities was achieved. A system suitability test to check the quality of the separation is specified. The method shows good repeatability, linearity and robustness. (c) 2009 Elsevier B.V. All rights reserved.
URI: 
ISSN: 0021-9673
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Pharmaceutical Analysis
× corresponding author
# (joint) last author

Files in This Item:

There are no files associated with this item.

Request a copy

 




All items in Lirias are protected by copyright, with all rights reserved.

© Web of science