Title: In vitro Antiviral Activity of some Novel Isatin Derivatives against HCV and SARS-CoV Viruses
Authors: Selvam, Periyasamy ×
Murgesh, N
Chandramohan, M
De Clercq, Erik
Keyaerts, Els
Vijgen, Leen
Maes, Piet
Neyts, Johan
Van Ranst, Marc #
Issue Date: Jan-2008
Publisher: Indian Pharmaceutical Association
Series Title: Indian Journal of Pharmaceutical Sciences vol:70 issue:1 pages:91-U17
Abstract: 4-[(1,2-dihydro-2-oxo-3H-indol-3-ylidene)amino]-N(4,6-dimethyl-2-pyrimidiny)benzene sulphonamide and its derivatives were evaluated for antiviral activity against Pathogenic viruses such as Hepatitis C Virus and SARSCoV in Vero and Huh 5-2 cells, respectively. The 5-fluoro derivative inhibited the HCV RNA synthesis at 6 mu g/ml, without toxicity at a concentration up to 42 mu g/ml in Huh 5-2 cells. Among the compounds tested SPIII-5F exhibits the 45% maximum protection against replication of SARS-CoV in Vero cells.
ISSN: 0250-474X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Clinical and Epidemiological Virology (Rega Institute)
Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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