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Title: Interaction between calcium-activated chloride channels and the cystic fibrosis transmembrane conductance regulator
Authors: Wei, L ×
Vankeerberghen, A
Cuppens, Harry
Eggermont, Jan
Cassiman, Jean-Jacques
Droogmans, Guillaume
Nilius, Bernd #
Issue Date: Oct-1999
Publisher: Springer verlag
Series Title: Pflügers Archiv : European journal of physiology. vol:438 issue:5 pages:635-41
Abstract: We investigated interactions between cystic fibrosis conductance regulator (CFTR) and endogenous Ca2+-activated Cl- channels (CaCC) in bovine pulmonary artery endothelium (CPAE). CPAE cells, which do not express CFTR, were transiently transfected with wild-type (WT) CFTR and the deletion mutant deltaF508 CFTR. Currents through CaCC were significantly reduced after expression of WT CFTR. This inhibition was increased by stimulation (isobutylmethylxanthine, forskolin) of CFTR in cells expressing WT CFTR. There were no such effects when deltaF508 mutant CFTR, which is retained in the endoplasmic reticulum, was expressed. It is concluded that CFTR and CaCC are functionally coupled probably through a direct channel-channel interaction.
ISSN: 0031-6768
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Department of Human Genetics - miscellaneous
Laboratory of Ion Channel Research
Human Mutations and Polymorphisms Section (-)
Physiology Section (-)
Department of Cellular and Molecular Medicine - miscellaneous
Laboratory of Cellular Transport Systems
Forensic Biomedical Sciences
× corresponding author
# (joint) last author

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