Title: Rapid clearance of the circulating metastatic factor autotaxin by the scavenger receptors of liver sinusoidal endothelial cells
Authors: Jansen, Silvia
Andries, Maria
Vekemans, Katrien
Vanbilloen, Hubert
Verbruggen, Alfons
Bollen, Mathieu # ×
Issue Date: Nov-2009
Publisher: Elsevier
Series Title: Cancer Letters vol:284 issue:2 pages:216-21
Abstract: Autotaxin, also known as NPP2 (nucleotide pyrophosphatase/phosphodiesterase 2), is a secreted lysophospholipase-D that generates lysophosphatidic acid and thereby promotes the metastatic and invasive properties of tumor cell as well as angiogenesis. We show here that, in mice, NPP2 is cleared from the circulation within minutes and is retained by the liver sinusoidal endothelial cells (LSECs). The binding of NPP2 to isolated LSECs resulted in its degradation and could be competed for with ligands of the scavenger receptor family. Our finding that circulating NPP2 has a rapid turnover has important implications for its development as an anti-cancer target.
ISSN: 0304-3835
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Biosignaling & Therapeutics
Laboratory of Abdominal Transplantation
× corresponding author
# (joint) last author

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