Title: Susceptibility to depression expressed as alterations in cortisol day curve: a cross-twin, cross-trait study
Authors: Wichers, Marieke C ×
Myin-Germeys, Inez
Jacobs, Nele
Kenis, Gunter
Derom, Cathérine
Vlietinck, Robert
Delespaul, Philippe
Mengelers, Ron
Peeters, Frenk
Nicolson, Nancy
Van Os, Jim #
Issue Date: Apr-2008
Series Title: Psychosomatic Medicine vol:70 issue:3 pages:314-8
Abstract: OBJECTIVE: To examine, using a cross-twin cross-trait design, the hypotheses 1) that the genetic and environmental susceptibility to depression is expressed, in part, as alterations in cortisol day curves and 2) that cortisol abnormalities are not merely the consequence of depressive states or the stressors associated with its onset. Alteration of diurnal secretion of cortisol is a possible endophenotype of depression, as depressed patients show alterations in cortisol dynamics over the day. METHODS: Salivary cortisol measurements were obtained in a sample of 279 twin pairs at 10 random times a day for 5 days. A structured clinical interview for DSM-IV (Diagnostic and Statistical Manual of Mental Disorders, 4th Edition) axis I mood disorder (SCID) was administered. Using multilevel regression analysis, the moderating influence of a lifetime diagnosis of depression in the co-twin on the association between time of day and cortisol concentrations in the proband twin was examined. RESULTS: Diurnal variation in cortisol in the proband twin differed as a function of lifetime diagnosis of depression in the co-twin. In addition, this moderating effect was significantly stronger for dizygotic than for monozygotic twins. CONCLUSIONS: Probands of co-twins with lifetime depression have a different diurnal cortisol profile than those without, suggesting that altered hypothalamic-pituitary-adrenal axis functioning is an indicator of depression susceptibility.
ISSN: 0033-3174
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Clinical Genetics
Department of Human Genetics - miscellaneous
Clinical Genetics Section (-)
× corresponding author
# (joint) last author

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