Title: Perinatal outcome of twin pregnancies in women of advanced age
Authors: Delbaere, Ilse ×
Verstraelen, Hans
Goetgeluk, Sylvie
Martens, Guy
Derom, Cathérine
De Bacquer, Dirk
De Backer, Guy
Temmerman, Marleen #
Issue Date: Sep-2008
Publisher: Published for the European Society of Human Reproduction and Embryology by IRL Press
Series Title: Human Reproduction vol:23 issue:9 pages:2145-2150
Abstract: BACKGROUND: The aim of this study was to assess the outcome of twin pregnancies in women of advanced age (>or=35 years) compared with women aged 25-29 years old. METHODS: This population-based retrospective study compared perinatal outcome of twin pregnancies in primiparae aged 35 or older (N = 240) to that of twin pregnancies in primiparae aged 25-29 years (N = 940). Observed outcomes are adjusted for intermediate (mode of conception and hypertension during pregnancy) and confounding variables (level of education). The possible effect of zygosity and chorionicity was tested in a subset of this database, recorded in the East Flanders Prospective Twin Survey (EFPTS). RESULTS: In twin pregnancies, maternal age of 35 or over is associated with a lower incidence of preterm birth [adjusted odds ratio (AOR) 0.59, 95% confidence interval (CI) 0.44-0.79] and low birthweight (AOR 0.75, 95% CI 0.58-0.98) compared with younger women. Differences in zygosity and chorionicity between both cohorts do not seem to affect the result. CONCLUSIONS: In comparison with primiparae aged 25-29 years, perinatal outcome of twin pregnancies is more favourable in primiparae aged 35 or over.
ISSN: 0268-1161
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Clinical Genetics
× corresponding author
# (joint) last author

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