Title: Does reactivity to stress cosegregate with subclinical psychosis? A general population twin study
Authors: Lataster, T ×
Wichers, M
Jacobs, N
Mengelers, R
Derom, Cathérine
Thiery, E
Van Os, J
Myin-Germeys, Inez #
Issue Date: Jan-2009
Publisher: Munksgaard
Series Title: Acta Psychiatrica Scandinavica vol:119 issue:1 pages:45-53
Abstract: OBJECTIVE: This study assessed the relationship between stress reactivity (trait 1) and psychosis (trait 2) across genetically related persons (cross-twin, cross-trait design) to examine whether stress reactivity is an uncontaminated and unconfounded familial marker of psychosis risk. METHOD: Reactivity to stress and subclinical psychotic experiences were assessed in 289 female, general population twin-pairs. Cross-trait, within-twin associations investigating the association between stress reactivity and subclinical psychotic experiences in each person, were calculated. In addition, cross-trait, cross-twin associations were calculated to assess whether stress reactivity in one twin was moderated by subclinical psychotic experiences in the co-twin. RESULTS: Cross-trait, within-twin analyses showed significant associations between stress reactivity and subclinical psychotic experiences in each person. In addition, the cross-trait cross-twin analyses showed that stress reactivity in twin 1 was significantly moderated by subclinical experiences in the co-twin. CONCLUSION: The results suggest that the psychosis phenotype cosegregates with increased emotional reactivity to stress in daily life.
ISSN: 0001-690X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Clinical Genetics
× corresponding author
# (joint) last author

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