Title: The role of interactions between phage and bacterial proteins within the infected cell: a diverse and puzzling interactome
Authors: Roucourt, Bart
Lavigne, Rob # ×
Issue Date: Nov-2009
Publisher: Blackwell Science
Series Title: Environmental Microbiology vol:11 issue:11 pages:2789-2805
Abstract: Summary Interactions between bacteriophage proteins and bacterial proteins are important for efficient infection of the host cell. The phage proteins involved in these bacteriophage-host interactions are often produced immediately after infection. A survey of the available set of published bacteriophage-host interactions reveals the targeted host proteins are inhibited, activated or functionally redirected by the phage protein. These interactions protect the bacteriophage from bacterial defence mechanisms or adapt the host-cell metabolism to establish an efficient infection cycle. Regrettably, a large majority of bacteriophage early proteins lack any identified function. Recent research into the antibacterial potential of bacteriophage-host interactions indicates that phage early proteins seem to target a wide variety of processes in the host cell - many of them non-essential. Since a clear understanding of such interactions may become important for regulations involving phage therapy and in biotechnological applications, increased scientific emphasis on the biological elucidation of such proteins is warranted.
ISSN: 1462-2912
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Division of Gene Technology (-)
Laboratory of Glycobiology and Developmental Genetics (-)
× corresponding author
# (joint) last author

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