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Title: Distribution of thymosin beta 4 in mouse tissues
Authors: Paulussen, Melissa ×
Landuyt, Bart
Luyten, Walter
Schoofs, Liliane
Arckens, Lut #
Issue Date: Jul-2008
Conference: Fens Forum of European Neurosciences edition:6 location:Geneva, Switzerland date:July, 12-16, 2008
Abstract: A large peptidomics study on mouse tissues and cell cultures identified thymosin beta 4 as an interesting peptide with a distinct expression pattern. Thymosin beta 4 is a peptide of 43 amino acids, originally identified as a major actin-sequestering peptide. Meanwhile, a broad range of functions have been attributed to thymosin beta 4. The peptide has been implicated in carcinogenesis, apoptosis, angiogenesis, blood coagulation and wound healing and it plays a role in immunology. However, its precise localization throughout the entire body of the mouse remains unclear. We therefore initiated a detailed investigation of its tissue distribution and cellular expression by in situ hybridization and immunocytochemistry. In the brain, thymosin beta 4 was clearly present in neurons and glia in the olfactory bulb, the neocortex, the hippocampus and the dentate gyrus. We further localized thymosin beta 4 in cells, typically with many processes as observed for brain tissue, inside the thymus, the white pulp of the spleen, lung, kidney, liver, adrenal gland, stomach and intestine. Remarkably, thymosin beta 4 was thus associated with microglia in the brain, and elsewhere with macrophages, the differentiated phagocytic cells residing in every tissue. These findings confirm its immunological function. In fact, it is known that the peptide plays a role after lesions in the brain through its association with microglia.
Publication status: published
KU Leuven publication type: IMa
Appears in Collections:Animal Physiology and Neurobiology Section - miscellaneous
Section Woman - Miscellaneous (-)
Department of Pharmaceutical & Pharmacological Sciences - miscellaneous
× corresponding author
# (joint) last author

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