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Title: Striatal and hippocampal analysis of arc and homer1a mRNA expression during visuo-motor learning in the Morris water maze
Authors: Laeremans, Annelies
Nys, Julie
Gantois, Ilse
D'Hooge, Rudi
Arckens, Lut #
Issue Date: 11-May-2009
Host Document: Acta Neurologica Belgica. Program and Abstract Book. pages:43
Conference: Bi-Annual Meeting of the Belgian Society for Neuroscience edition:8 location:Liège date:11 May 2009
Article number: 51
Abstract: Literature states that the striatum and the hippocampus are two important brain areas for visuo-motor learning since neural mechanisms and changing activation patterns within these areas are involved in the processing of visual stimuli and the subsequent motor act.
The neural activity of mice trained in the Morris water maze was molecularly characterized by in situ hybridization for the immediate early gene activity markers arc and homer1a and this in two timeframes, namely the early learning and the late learning (overtrained/automatization) phase. First results show that in the early learning phase the mRNA expression of both arc and homer1a is upregulated in the ventrolateral striatum. In the overtrained phase a different dynamic for these two immediate early genes is noticeable: while the upregulation of arc mRNA expression shifts to the dorsal striatum, homer1a mRNA continues to be upregulated in the ventrolateral striatum. Arc and homer1a mRNA expression levels in the hippocampus indicate that this structure is more active in the early learning phase compared to the automatization phase. Further analysis will reveal how differential molecular activity in the subregions of hippocampus and striatum relates to both phases of the visuo-motor learning process.
ISSN: 0300-9009
Publication status: published
KU Leuven publication type: AMa
Appears in Collections:Animal Physiology and Neurobiology Section - miscellaneous
Laboratory for Biological Psychology
# (joint) last author

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