Title: Gold Electrode Incorporating Corrole as an Ion-Channel Mimetic Sensor for Determination of Dopamine
Authors: Kurzatkowska, Katarzyna ×
Dolusic, Eduard
Dehaen, Wim
Sieron-Stoltny, Karolina
Sieron, Aleksander
Radecka, Hanna #
Issue Date: Sep-2009
Publisher: Amer chemical soc
Series Title: Analytical Chemistry vol:81 issue:17 pages:7397-7405
Abstract: Here, we report on an ion-channel mimetic sensor using self-assembly monolayers deposited onto gold electrodes for electrochemical determination of dopamine. The different compositions of the modification solution consist of corrole-SH and other thiol derivatives used as the "background compounds" such as 1-dodecanethiol (DDT), 6-mereapto-1-hexanol (HS(CH2)(6)OH), or 11 -mercapto-1-undecanol (HS(CH2)(11)OH) were explored to find the best self-assembled monolayer (SAM) suitable for dopamine determination. Among them, the mixed SAM consisting of corroles with the -SH group and 6-mercapto-1-hexanol (HS(CH2)(6)OH) in the molar ratio 1:10 was the most sensitive. The signals generated by the formation of a complex between the corrole host and the dopamine guest were measured by Osteryoung square-wave voltammetry (OWN) and electrochemical impedance spectroscopy (EIS) with [Ru(NH3)(6)](3+) as an electroactive marker. The developed sensor was free of interferences of components, of human plasma such as ascorbic acid, creatinine, creatine, and uric acid. The detection limits observed by EIS in buffer solution and in the presence of centrifuged human plasma 80 times diluted with a 0.9% NaCl containing 0.01 M borate buffer solution of pH 7.0 were 3.3 x 10(-12) and 5.3 x 10(-12) M, respectively.
ISSN: 0003-2700
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Design and Synthesis
× corresponding author
# (joint) last author

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