Title: Prevalence and epidemiology of HIV type 1 drug resistance among newly diagnosed therapy-naive patients in Belgium from 2003 to 2006
Authors: Vercauteren, Jurgen ×
Derdelinckx, Inge
Sasse, André
Bogaert, Marleen
Ceunen, Helga
De Roo, Ann
De Wit, Stephane
Deforche, Koen
Echahidi, Fedoua
Fransen, Katrien
Goffard, Jean-Christophe
Goubau, Patrick
Goudeseune, Elodie
Yombi, Jean-Cyr
Lacor, Patrick
Liesnard, Corinne
Moutschen, Michel
Pierard, Denis
Rens, Roeland
Schrooten, Yoeri
Vaira, Dolores
Van Den Heuvel, Annelies
Van Der Gucht, Bea
Van Ranst, Marc
Van Wijngaerden, Eric
Vandercam, Bernard
Vekemans, Marc
Verhofstede, Chris
Clumeck, Nathan
Vandamme, Anne-Mieke
Van Laethem, Kristel #
Issue Date: Mar-2008
Publisher: Mary Ann Liebert, Inc.
Series Title: AIDS Research and Human Retroviruses vol:24 issue:3 pages:355-362
Abstract: This study is the first prospective study to assess the prevalence, epidemiology, and risk factors of HIV-1 drug
resistance in newly diagnosed HIV-infected patients in Belgium. In January 2003 it was initiated as part of
the pan-European SPREAD program, and continued thereafter for four inclusion rounds until December
2006. Epidemiological, clinical, and behavioral data were collected using a standardized questionnaire and
genotypic resistance testing was done on a sample taken within 6 months of diagnosis. Two hundred and
eighty-five patients were included. The overall prevalence of transmitted HIV-1 drug resistance in Belgium
was 9.5% (27/285, 95% CI: 6.6–13.4). Being infected in Belgium, which largely coincided with harboring a
subtype B virus, was found to be significantly associated with transmission of drug resistance. The relatively
high rate of baseline resistance might jeopardize the success of first line treatment as more than 1 out of 10
(30/285, 10.5%) viruses did not score as fully susceptible to one of the recommended first-line regimens, i.e.,
zidovudine, lamivudine, and efavirenz. Our results support the implementation of genotypic resistance testing
as a standard of care in all treatment-naive patients in Belgium.
ISSN: 0889-2229
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Clinical and Epidemiological Virology (Rega Institute)
Laboratory for Clinical Infectious and Inflammatory Disorders
× corresponding author
# (joint) last author

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